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purM [2017-8-11 16:0:3]
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purM [2017-8-11 16:0:3]

phosphoribosylaminoimidazole synthetase
Locus
BSU06500
Isoelectric point
4.59
Molecular weight
36.90 kDa
Protein length
346 aa Sequence Blast
Gene length
1038 bp Sequence Blast
Function
purine biosynthesis
Product
phosphoribosylaminoimidazole synthetase
Essential
no
E.C.
6.3.3.1
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Nucleotide metabolism → Biosynthesis/ acquisition of nucleotides → Biosynthesis/ acquisition of purine nucleotides

    • Gene

    Coordinates
    706,973 → 708,013

    The protein

    Catalyzed reaction/ biological activity

  • ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole (according to Swiss-Prot)

    • Protein family

  • AIR synthase family (according to Swiss-Prot)

    • Structure

  • 2BTU (from Bacillus anthracis, 64% identity, 78% similarity)

    • Localization

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    Genes
    purE-purK-purB-purC-purS-purQ-purL-purF-purM-purN-purH-purD
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • G-box: termination, (riboswitch) PubMed, in G-box
  • PurR: repression, (molecular inducer: PRPP) PubMed, in PurR regulon

    • Regulation

  • expression activated by glucose (4.4 fold) PubMed
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    Biological materials

    Mutant

  • 1A601 ( purM::erm), PubMed, available at BGSC

    • References

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